Vacature

Technician Downstream Process Development

Locatie

Amsterdam

Vacature omschrijving

Work for an Organization that brings innovative therapies to patients worldwide!

The Process Development (PD) department is an essential part of the company which is taking the lead for the in-house development, scale-up and manufacture of novel gene therapies. The downstream processing (DSP) team is responsible for the recovery and purification of the biopharmaceutical from the bioreactor harvest through a sequence of unit operations, including cell lysis, filtration, chromatography and UF/DF. The DSP team will also support tech-transfer to Contract Manufacturing Organisations (CMOs) to support the manufacture of AAV-based gene therapies for clinical trials.  

Main responsibilities of the role:

  • As a Technician, you are involved in the practical day-to-day lab work, data analysis and reporting of results
  • The Technician prepares, plans and executes experimental work related to Downstream Bioprocessing, such as chromatography and filtration within set timelines; this will be supported by the Scientist Downstream Process Development
  • The Technician is involved in the operation and maintenance of small and pilot scale laboratory equipment
  • The role will also include time to provide analytical support (analysis of in-process samples and final drug substance) to support development programs
  • Communicates the daily work and results obtained to the Scientist Downstream Process Development.

Eisen

  • MSc, or HBO/BSc, or equivalent, with a minimum of 2 years of relevant working experience
  • Hands on experience with small scale chromatography and ultrafiltration equipment required, preferably with AKTA systems
  • Familiarity with cell culturing and analytical methods, such as SDS-PAGE, BCA assays, ELISAs is a plus
  • You are thorough and have an eye for detail. You deliver highly precise work and work consistently and in a steady pace.

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